IL11RA HEK293
CBP74571
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| I. Background | |
| IL11RA(白介素-11受體α亞基)是由3590號基因編碼的I型細胞因子受體。它是IL-11信號傳導(dǎo)的關(guān)鍵受體,需要與gp130分子共同形成復(fù)合物才能向細胞內(nèi)傳遞信號。 IL11RA在顱面部骨骼和牙齒的正常發(fā)育中發(fā)揮重要作用,其功能缺失可導(dǎo)致顱縫早閉及牙齒發(fā)育異常綜合征(CRSDA)。在疾病方面,IL11RA參與心臟纖維化、胰腺炎及腫瘤耐藥等過程,近年已成為骨肉瘤CAR-T治療的潛在靶點。 | |
| II. Description | |
| IL11RA HEK293細胞,在 HEK293細胞的基礎(chǔ)上,穩(wěn)定表達 IL11RA 。 | |
| III. Introduction | |
| Expressed gene: | IL11RA |
| Host Cell: | HEK293 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
![]() Figure 1. Recombinant IL11RA HEK293 constitutively expressing IL11RA. |
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