hDPP4/MC-38
CBPG0269
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產(chǎn)品描述
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| I. Background | |
| DPP4基因編碼二肽基肽酶4，是一種多功能跨膜糖蛋白，也是免疫分子CD26。它的核心功能是通過酶活性快速降解胰高血糖素樣肽-1（GLP-1）等腸促胰島素，從而負(fù)向調(diào)控血糖，因此成為2型糖尿病治療藥物（如西格列汀）的重要靶點(diǎn)。同時(shí)，它在免疫系統(tǒng)中作為T細(xì)胞共刺激分子發(fā)揮作用，并且是中東呼吸綜合征冠狀病毒（MERS-CoV）入侵細(xì)胞的功能性受體，廣泛參與血糖調(diào)節(jié)、免疫應(yīng)答和病毒感染等多種生理病理過程。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | hDPP4 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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