hTNFR2/CT26
CBPG0266
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產品描述
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| I. Background | |
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TNFR2(腫瘤壞死因子受體2,CD120b)是腫瘤壞死因子受體超家族成員,編碼基因 位于人類1 號染色體1p36 .22 區(qū)域,編碼439 個氨基酸的單程跨膜糖蛋白。其核心特征為 在免疫抑制細胞(如調節(jié)性T 細胞Tregs、髓源抑制性細胞MDSCs)及腫瘤細胞表面高表 達,而正常組織表達受限,通過與腫瘤壞死因子(TNF)結合激活NF-κB、MAPK、 PI3K/Akt 等信號通路,介導細胞存活、增殖及免疫調節(jié)功能。
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| II. Introduction | |
| Host Cell: | CT26.WT |
| Expressed gene: | TNFR2 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS+10 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
III. Representative Data![]() Figure 1. Recombinant hTNFR2/CT26 stably expressing hTNFR2. |
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