hAMHR2/MC-38
CBPG0259
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產(chǎn)品描述
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| I. Background | |
| AMHR2（抗苗勒管激素受體 2 型）是轉(zhuǎn)化生長(zhǎng)因子-β（TGF-β）超家族關(guān)鍵受體，位于染色體 12q13，由 11 個(gè)外顯子編碼 573 個(gè)氨基酸的跨膜蛋白，含胞外結(jié)合域、跨膜區(qū)及 胞內(nèi)絲氨酸/蘇氨酸激酶結(jié)構(gòu)域。其核心功能是與抗苗勒管激素（AMH）結(jié)合，調(diào)控性別 分化：在男性胚胎期，AMH 由睪丸支持細(xì)胞分泌，結(jié)合 AMHR2 后激活 SMAD 信號(hào)通路，促使苗勒管退化，確保男性生殖系統(tǒng)正常發(fā)育；女性因缺乏 AMH，苗勒管發(fā)育為子宮、輸卵管等。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | AMHR2 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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