hSLC39A6(LIV-1)/MC-38
CBPG0188
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| I. Background | |
| SLC39A6 也稱為 LIV-1 或 ZIP6，是鋅轉運蛋白家族的成員，最初被確定為乳腺癌中的 雌激素誘導基因。SLC39A6 的主要功能是將鋅離子從細胞外轉移至細胞內，并且是酶、轉 錄因子和信號分子發(fā)揮作用機制中的關鍵蛋白。該基因在多種腫瘤細胞（如乳腺癌、前列 腺癌、食管癌等）中高表達，而在正常組織中表達有限，成為抗體偶聯藥物（ADC）治療 的潛在靶點。研究表明 SLC39A6 通過調節(jié)鋅離子水平影響細胞信號傳導通路（如 JAK/STAT、PI3K/AKT 等），促進腫瘤增殖、侵襲和遷移，并與上皮間質轉化（EMT）相 關，通過調控 Snail 等轉錄因子增強細胞遷移能力。在臨床試驗中，靶向 SLC39A6 的 ADC 藥物已顯示出對轉移性三陰性乳腺癌等癌癥的治療效果，凸顯其在癌癥治療中的重要性。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | hSLC39A6(LIV-1) |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+5μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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| V. In VIVO Data | |
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Index |
Content |
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Animal |
C57BL/6J, 7weeks, female |
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Implanted Position |
Subcutaneous (right flank region) |
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Injected Cell Numbers |
1×10^6/0.1ml |
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Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hSLC39A6(LIV-1)/MC38 Mean Body Weight ± SEM.
2. Tumor Volume
Figure 3. hSLC39A6(LIV-1)/MC38 Mean Tumor Volume ± SEM.
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
