hLRRC15/MC-38
CBPG0108
詢 價(jià)
留 言
產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫(kù)
| I. Background | |
| LRRC15（Leucine Rich Repeat Containing 15），富含 15 個(gè)亮氨酸的重復(fù)序列，是 LRRC 超家族的成員之一。LRRC15 同時(shí)能夠正調(diào)控細(xì)胞的遷移，調(diào)控受體介導(dǎo)的病毒粒子與宿主細(xì)胞的附著，且蛋白質(zhì)定位于細(xì)胞質(zhì)膜。LRRC15 主要是以蛋白-蛋白和蛋白-基質(zhì) 相互作用方式，參與細(xì)胞-細(xì)胞和/或-細(xì)胞外基質(zhì)的相互作用，參與炎性反應(yīng)相關(guān)疾病，同時(shí)在細(xì)胞粘附、信號(hào)轉(zhuǎn)導(dǎo)、DNA 修復(fù)等過(guò)程中有重要作用。LRRC15 在正常組織中的低表達(dá)，而在骨肉瘤、卵巢癌、乳腺癌、胰腺導(dǎo)管腺癌、促結(jié)締組織增生型小圓細(xì)胞癌等癌癥 中高表達(dá)。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | hLRRC15 |
| Stability: | 32 passages |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+5μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
|
|
|
| V. In VIVO Data | |
|
Index |
Content |
|
Animal |
C57BL/6J, 6weeks, female |
|
Implanted Position |
Subcutaneous (right lower flank region) |
|
Injected Cell Numbers |
1×10^6/0.1ml |
|
Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hLRRC15/MC38 Mean Body Weight ± SEM.
2. Tumor Volume
Figure 3. hLRRC15/MC38 Mean Tumor Volume ± SEM.
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
